Publications by authors named "S Albac"
Article Synopsis
- Cefepime/enmetazobactam is a new antibiotic duo effective against multidrug-resistant Enterobacterales, particularly strains producing OXA-48 enzymes, with potential use in treating hospital-acquired pneumonia.
- In a mouse study, combining cefepime with enmetazobactam significantly reduced bacterial levels in the lungs compared to treatment with either drug alone or with meropenem, especially against high-resistance strains.
- These findings suggest cefepime/enmetazobactam could be a promising alternative for tackling lung infections caused by resistant Enterobacterales, demonstrating better antibacterial activity than currently used treatments.
Carbapenem-resistant (CRAB) is an emerging cause of hospital-acquired pneumonia (HAP). Preclinical large models are warranted to predict the efficacy and the resistance profile of anti-infectives and mimic how they will be used in the human treatment of CRAB-HAP. Here we reported on the development of an experimental pneumonia model in immunocompromised rabbits, receiving a 48-h human-simulated regimen.
View Article and Find Full Text PDFMethicillin-resistant (MRSE) contributes to a high percentage of orthopedic infections, and their treatment represents a huge challenge. The present study aimed to evaluate the efficacy of ceftaroline alone or combined with rifampin in a rat MRSE osteomyelitis model and the bone penetration of ceftaroline. A ceftaroline monotherapy showed a significant bacterial reduction in infected bones after a 7-day period of treatment.
View Article and Find Full Text PDFDespite significant advancements in material science, surgical site infection (SSI) rates remain high and prevention is key. This study aimed to demonstrate the in vivo safety and antibacterial efficacy of titanium implants treated with a novel broad-spectrum biocidal compound (DBG21) against methicillin-resistant Staphylococcus aureus (MRSA). Titanium (Ti) discs were covalently bound with DBG21.
View Article and Find Full Text PDFObjectives: As daptomycin adjunction is currently under clinical evaluation in the multicentre phase II AddaMAP study to improve the prognosis of pneumococcal meningitis, the present work aimed at evaluating the in vitro antimicrobial activity of daptomycin-based combinations against some of the most frequent species responsible for bacterial meningitis.
Methods: Clinically relevant strains of Streptococcus pneumoniae, Listeria monocytogenes, Haemophilus influenzae and Neisseria meningitidis were obtained from National Reference Centers. The antimicrobial activity of amoxicillin, cefotaxime and rifampicin, either alone or in association with daptomycin, was explored through the determination of minimum inhibitory concentration (MIC) and fractional inhibitory concentration index (FICI) as well as time-kill assay (TKA) using the broth microdilution method.