Publications by authors named "S Alatab"
Background: Biological medications have played a significant role in maintenance therapy for Crohn's disease (CD), but some cases become refractory to these agents. Methotrexate (MTX) appears to be a cost-effective and readily available drug for enhancing the effectiveness of maintenance therapy when used in combination with anti-tumor necrosis factor (anti-TNF) therapy in such cases. However, its effectiveness is still to be established.
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- Ulcerative colitis (UC) is an inflammatory bowel disease that causes inflammation in the rectum and colon, with a rising prevalence especially in developed countries and a potential link to colorectal cancer (CRC).
- The study analyzed data from 91 UC patients who underwent colectomy to identify risk factors for dysplasia, noting that older age was a significant risk factor but found no other strong associations.
- The findings highlight the importance of age in assessing dysplasia risk for UC patients, suggesting that older patients may need more careful management and screening for CRC; more research is needed to confirm these results.
Article Synopsis
- A nationwide study in Iran investigated age and sex differences in outcomes among patients with Inflammatory Bowel Disease (IBD), utilizing data from the Iranian Registry of Crohn's and Colitis (IRCC).
- The analysis covered 9,392 adult IBD patients and revealed that male Crohn's disease (CD) patients had higher odds of active disease compared to females, while the opposite was true for ulcerative colitis (UC) patients.
- The study highlights the significance of incorporating age and sex differences into IBD understanding, which may help improve management strategies and promote personalized care for affected individuals.
Human cytomegalovirus (HCMV) is classified within the order and is prevalent in 50%‒80% of the general population. Most carriers experience this infection without noticeable clinical symptoms. HCMV causes a lifelong latent infection that can be reactivated due to immune disorders and inflammation.
View Article and Find Full Text PDFBackground: Data on the epidemiology of inflammatory bowel disease (IBD) in the Middle East are scarce. We aimed to describe the clinical phenotype, disease course, and medication usage of IBD cases from Iran in the Middle East.
Methods: We conducted a cross-sectional study of registered IBD patients in the Iranian Registry of Crohn's and Colitis (IRCC) from 2017 until 2022.