Publications by authors named "S Akita"
Background: Previously, we proposed that the immune-modified Glasgow Prognostic Score (imGPS), which adds the lymphocyte count to the mGPS, is helpful as a prognostic marker for patients with head and neck squamous cell carcinoma. In this study, we investigated the imGPS as a marker for the therapeutic effect of pembrolizumab in treating recurrent and metastatic head and neck cancer (RMHNC).
Methods: This study included RMHNC patients who were treated with pembrolizumab from December 2019 to April 2024.
Purpose: To investigate the surgical safety and benefits of using the BirdView camera system with a wide field of view in robotic surgery for rectal cancer in a prospective clinical study.
Methods: This study included 20 consecutive patients who underwent robotic surgery at our institution between the years 2022 and 2023. The primary endpoint was perioperative safety, which was defined as the occurrence of adverse events, including other organ injuries and malfunctions, caused by the BirdView camera system.
Article Synopsis
- Brown seaweeds are vital to coastal ecosystems, but they are threatened by climate change, prompting a detailed genetic study.
- The research traced the evolutionary history of brown algae, highlighting significant gene families and metabolic pathways related to their adaptation and functional diversity.
- Findings also indicated that the integration of large viral genomes has played a crucial role in shaping the genetics and traits of brown algal species over time.
Background: Platelet-rich plasma (PRP), which is prepared by concentrating platelets in autologous blood, shows efficacy in chronic skin wounds via multiple growth factors. However, it exhibits heterogeneity across patients, leading to unstable therapeutic efficacy. Human induced pluripotent stem cell (iPSC)-derived megakaryocytes and platelets (iMPs) are capable of providing a stable supply, holding promise as materials for novel platelet concentrate-based therapies.
View Article and Find Full Text PDFArticle Synopsis
- Transoral surgery is effective for early-stage pharyngeal and laryngeal cancer, offering good local control with less invasiveness compared to external incisions, but criteria for postoperative treatment remain unclear.
- In a study of 70 patients at Gifu University Hospital, high rates of positive surgical margins were found (38.6% horizontal, 27.1% vertical), yet overall survival rates were strong, with 77.1% surviving five years post-surgery.
- Horizontal margin positivity correlated with worse outcomes, while vascular invasion wasn't significantly linked to prognosis, indicating a need for more research to establish clear postoperative treatment guidelines.