Publications by authors named "S Akiba"
Article Synopsis
- * A colonoscopy revealed a significant amount of hard stool in the sigmoid colon, along with ulcers and erosions in the proximal area.
- * After the procedure, the patient's symptoms improved, but the decline in intestinal function from ischemic enteritis may have led to the obstruction; fecal obstructive enterocolitis is rare, highlighting the need for careful preparation during colonoscopy.
Article Synopsis
- Bioimaging techniques like magnetic resonance are currently used to track atherosclerotic plaques made up of foam cells formed from macrophages that ingest oxidized low-density lipoprotein (oxLDL), but these methods lack specificity and sensitivity.
- This study tested iodine-125-labeled oxLDL (I-oxLDL) as a new radiotracer for better detection of foam cells in atherosclerotic plaques using various imaging techniques.
- Results showed that macrophages effectively took up I-oxLDL, allowing a notable radioactive signal to be detected in atherosclerotic plaques, indicating I-oxLDL's potential to enhance bioimaging techniques in the future.
Nonalcoholic steatohepatitis (NASH) is characterized by hepatic inflammation and fibrosis due to excessive fat accumulation. Monocyte chemoattractant protein-1 (MCP-1) is a key chemokine that infiltrates inflammatory cells into the liver during the development of NASH. Our previous studies demonstrated that a systemic deficiency of group IVA phospholipase A (IVA-PLA), an enzyme that contributes to the production of lipid inflammatory mediators, protects mice against high-fat diet-induced hepatic fibrosis and markedly suppresses the CCl-induced expression of MCP-1 in the liver.
View Article and Find Full Text PDFA 66-year-old woman with rheumatoid arthritis (RA) who had been receiving methotrexate (MTX) for 2 years presented with tarry stools. Contrast-enhanced computed tomography (CT) of the abdomen revealed irregular wall thickening in the ileocecal region and multiple low-contrast masses in both lobes of the liver. Lower gastrointestinal endoscopy revealed a type 2 tumor in the ileocecal region with a semi-peripheral ulcer.
View Article and Find Full Text PDFBackground/aim: Individuals with Down syndrome (DS), attributed to triplication of human chromosome 21 (Hsa21), exhibit a reduced incidence of solid tumors. However, the prevalence of glioblastoma among individuals with DS remains a contentious issue in epidemiological studies. Therefore, this study examined the gliomagenicity in Ts1Cje mice, a murine model of DS.
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