Early specialization in formative basketball: A machine learning analysis of shooting patterns in U14 and professional players.

Growing evidence supports that early sport specialization in children and adolescents may compromise long-term athlete development and high-performance acquisition. This study aimed to determine the presence of specialised shooting roles in formative men's basketball players compared to professionals. Data from shot charts of U14 and professional basketball players during the 2020-21 and 2021-22 seasons were retrieved.

Acid-exposed and hypoxic cancer cells do not overlap but are interdependent for unsaturated fatty acid resources.

Cancer cells in acidic tumor regions are aggressive and a key therapeutic target, but distinguishing between acid-exposed and hypoxic cells is challenging. Here, we use carbonic anhydrase 9 (CA9) antibodies to mark acidic areas in both hypoxic and respiring tumor areas, along with an HRE-GFP reporter for hypoxia, to isolate distinct cell populations from 3D tumor spheroids. Transcriptomic analysis of CA9-positive, hypoxia-negative cells highlights enriched fatty acid desaturase activity.

The Persistence of Biologic Therapies for Psoriatic Arthritis: A Narrative Review.

Drug persistence is a crucial measure of long-term efficacy, safety, and patient satisfaction. Lack of persistence can increase healthcare costs and morbidity and mortality rates. This review aimed to consolidate available data on drug persistence for various biological treatments used as the primary intervention for psoriatic arthritis and identify factors associated with nonpersistence.

In situ endoscopic photodynamic therapy combined with immature DC vaccination induces a robust T cell response against peritoneal carcinomatosis.

Background: Immunogenic cell death (ICD) and ferroptosis have recently emerged as key factors in the anticancer immune response. Among the treatments able to induce ICD and the associated release of danger signals is photodynamic therapy (PDT). Ferroptosis for its part results from lipid peroxidation and is induced by CD8 T cells to kill nearby cancer cells on IFN-γ production.

Neuromuscular Load in Professional Women's Handball: Segmentation of the Player Load and the Impacts at Group and Individual Level.

Handball is a team sport characterised by physical interaction with other opponents. This interaction produces a high load on the players that can manifest itself in various ways, from discomfort to prolonged injuries due to tears caused by excessive load. In order to establish correct protocols for application in women's teams, context- and gender-specific reference data must be available.