Publications by authors named "S Agampodi"
Article Synopsis
- The study investigates the role of Toll-like receptor 2 (TLR2) in leptospirosis, a disease not well understood in relation to TLR2 involvement.
- A systematic review was conducted on various studies with 35 articles selected, analyzing TLR2's expression and its association with immune responses during leptospirosis.
- Results showed that while TLR2 was more consistently expressed in experiments, human data yielded mixed findings, indicating a need for more research on TLR2's role in human leptospirosis and its interaction with other receptors like TLR4 and TLR5.
Investigating disease awareness of cutaneous leishmaniasis in rural Sri Lanka to inform public health services: a cross-sectional study.
BMJ Open
November 2024
Objective: To assess community awareness of cutaneous leishmaniasis (CL) in a disease-endemic district in Sri Lanka.
Design: Population-based cross-sectional study.
Setting: This study was conducted in selected 158 Grama Niladhari divisions covering all the 22 Divisional Secretariat areas of the Anuradhapura district, Sri Lanka.
Observational studies on COVID-19 vaccine effectiveness (VE) have provided critical real-world data, informing public health policy globally. These studies, primarily using pre-existing data sources, have been indispensable in assessing VE across diverse populations and developing sustainable vaccination strategies. Cohort design is frequently employed in VE research.
View Article and Find Full Text PDFAssessment of the productivity loss due to leading maternal ill-health conditions: a follow-up study of a prospective pregnancy cohort in rural Sri Lanka.
BMJ Open
October 2024
Objectives: This study aimed to assess the productivity loss and cost due to maternal ill-health conditions and its associated factors throughout pregnancy in rural Sri Lanka.
Design: A follow-up study of women registered in the Rajarata Pregnancy Cohort (RaPCo).
Setting: Anuradhapura district, Sri Lanka.
Article Synopsis
- The study focuses on non-Hardjo isolates of leptospirosis bacteria from human patients in Sri Lanka, revealing their complete genomes, which are less decayed compared to previously analyzed strains.
- The seven isolates, classified as a novel serovar, showed a lower number of pseudogenes and insertion sequences than earlier Hardjo genomes, indicating a potentially more functional genetic makeup.
- Findings suggest these Sri Lankan isolates exhibit unique pathogenic traits, including an increased number of specific virulence factor proteins, indicating a need for further research to understand leptospirosis mechanisms.