Publications by authors named "S Adi Harel"
Angiopoietin-1 (Ang-1) and its receptor Tie-2 promote vascular integrity and angiogenesis. MicroRNAs (miRNAs) are involved in the regulation of many cellular functions, including endothelial cell (EC) survival, proliferation, and differentiation. Several reports indicate that these effects of miRNAs on EC functions are mediated through the modulation of angiogenesis factor signaling including that of vascular endothelial growth factor (VEGF).
View Article and Find Full Text PDFInflammatory form of Waldenström macroglobulinemia (iWM) predicts outcomes after immuno-chemotherapy and Bruton tyrosine kinase inhibitors, but its origin is unknown. Here, we unravel increased clonal hematopoiesis in patients with iWM (61% vs 23% in noninflammatory WM), suggesting a contribution of environmental cells to iWM.
View Article and Find Full Text PDFArticle Synopsis
- The text discusses how cellular membrane balance (homoeostasis) is maintained through regulated transport processes between organelles involved in endocytosis and secretion.
- This process is facilitated by adaptor protein complexes (APs) that are recruited by the small GTPase ARF1, aiding in cargo selection for membrane trafficking.
- The study identifies two distinct roles of ARF1 compartments in facilitating secretory cargo export from the Golgi and recycling of materials from endosomes, challenging the conventional understanding of vesicle transport.
Article Synopsis
- This study evaluated the effectiveness of cardiac magnetic resonance (CMR) imaging compared to other diagnostic markers in predicting mortality in patients with AL cardiac amyloidosis (CA).
- Conducted on 176 patients with a median age of 68 years, the study found that high levels of NT-proBNP and troponin, along with low heart function measurements, were linked to increased mortality risk.
- Extracellular volume (ECV) from CMR emerged as a strong independent predictor of all-cause mortality and heart failure hospitalizations, suggesting it can enhance prognostic assessments beyond the established Mayo Clinic staging.