[Pure lower motoneurone syndrome in a series of six patients].

Introduction: Lower motoneurone syndromes (SMNI) have been defined by their clinical pattern, anomalies in nerve conduction and the presence of antiglycolipid antibodies. The possible response to immunotherapy is another characteristic which makes these syndromes interesting.

Patients And Methods: We studied the clinical and electrophysiological data, clinical progress and response to treatment of a series of six patients, with a pure lower motoneurone syndrome, with a follow up period of between 5 and 13 years.

Objective assessment of the sympatholytic action of the Nei-Kuan acupoint.

From animal experiments and clinical trials, we can think that acupuncture of Nei-Kuan (EH-6) is effective in the control of some vegetative functions. We have tried to determine the real reach of these assumptions by means of simple quantitative measurement methods, such as detection of cardiac frequency and systolic and diastolic blood pressure, and the sympathetic electrical response. The experiments were performed on 29 healthy volunteers.

[Modifications of sympathetic tone induced by acupuncture reflex. Sympathetic electrical response and stimulus of 6PC].

Introduction: From certain experimental data obtained by experimental myocardial perfusion and clinical and animal studies, it would seem that this corroborates the finding that puncture of the acupuncture point (Neiguan, 6PC) has an effect on organic vegetative tone.

Objective: We aimed to establish, by means of a simple, conclusive, objective measuring system such as sympathetic electrical response, whether this point had this action and whether its effect was nonspecific or due to activation of a nervous tract subjacent to this point.

Patients And Methods: We assessed the sympathetic electrical response in 29 healthy volunteers in whom basal values were recorded and again after orthodox acupuncture stimulus in 6PC, and compared with data obtained of the effects caused by stimulus of an extra-acupunctural point, of a different acupunctural point of the same channel, of bipolar stimulation of the median nerve at the level of 6PC and with the modifications generated in the response by rest lying down during the period of the experiment.

Reversible peripheral neuropathy induced by a single administration of high-dose paclitaxel.

Peripheral neuropathy (PN) is the main side effect with cycles of paclitaxel at standard doses (175 mg/m2 for 21 days). Administration of a single high-dose paclitaxel (HDP) is a novel approach for the treatment of cancer. We have prospectively measured neurotoxicity induced by HDP during a phase I trial.