Publications by authors named "S Achterberg"
Objective: High-flow nasal oxygen (HFNO) therapy is frequently applied outside ICU setting in hypoxemic patients with COVID-19. However, safety concerns limit more widespread use. We aimed to assess the safety and clinical outcomes of initiation of HFNO therapy in COVID-19 on non-ICU wards.
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- Prone positioning has emerged as a key treatment for mechanically ventilated COVID-19 patients, but it requires significant labor and can have negative effects, making it essential to identify which patients will benefit from the procedure.
- A study utilized data from over 1,100 intubated patients across 25 hospitals in the Netherlands, applying various machine learning models to predict the success of prone positioning after 4 hours by evaluating improvements in respiratory metrics.
- Despite extensive analysis using different machine learning techniques, the study found that distinguishing between patients who would respond positively to prone positioning and those who would not had limited success, indicating potential challenges in predicting treatment outcomes.
Assess and validate predictive performance of models for in-hospital mortality in COVID-19 patients: A retrospective cohort study in the Netherlands comparing the value of registry data with high-granular electronic health records.
Int J Med Inform
November 2022
Purpose: To assess, validate and compare the predictive performance of models for in-hospital mortality of COVID-19 patients admitted to the intensive care unit (ICU) over two different waves of infections. Our models were built with high-granular Electronic Health Records (EHR) data versus less-granular registry data.
Methods: Observational study of all COVID-19 patients admitted to 19 Dutch ICUs participating in both the national quality registry National Intensive Care Evaluation (NICE) and the EHR-based Dutch Data Warehouse (hereafter EHR).
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- This study examined catheter-related infections in critically ill COVID-19 patients, focusing on how common these infections are and their impact on patient mortality.
- Findings showed a prevalence of 7.9% for suspected infections, with an incidence rate of 9.4 per 1,000 catheter days.
- The research identified prone ventilation lasting over 5 days as a significant risk factor, and patients with suspected infections had a 78% higher risk of death compared to those without infections.
Effect of intensive care unit-specific virtual reality (ICU-VR) to improve psychological well-being in ICU survivors: study protocol for an international, multicentre, randomised controlled trial-the HORIZON-IC study.
BMJ Open
September 2022
Introduction: A substantial proportion of intensive care unit (ICU) survivors develop psychological impairments after ICU treatment, part of the postintensive care syndrome, resulting in a decreased quality of life. Recent data suggest that an ICU-specific virtual reality intervention (ICU-VR) for post-ICU patients is feasible and safe, improves satisfaction with ICU aftercare, and might improve psychological sequelae. In the present trial, we firstly aim to determine whether ICU-VR is effective in mitigating post-traumatic stress disorder (PTSD)-related symptoms and secondly to determine the optimal timing for initiation with ICU-VR.
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