Publications by authors named "S Accacha"
Article Synopsis
- Hyperglycemia in diabetes leads to the buildup of Advanced glycation end products (AGEs), which is linked to cardiovascular issues via their impact on cholesterol levels.
- The study investigated how plasma from poorly controlled adolescents with type 1 diabetes affects cholesterol handling in human macrophages, using THP-1 cells in a lab setting.
- Findings revealed that T1D plasma increased certain proteins related to cholesterol uptake and foam cell formation, suggesting that AGEs exacerbate atherosclerosis in diabetes by disrupting cholesterol transport processes.
The aim of this study was to describe rates of telemedicine use 18 months after the start of the coronavirus disease 2019 pandemic and to assess the institutional barriers to its implementation for type 1 diabetes care across centers of the T1D Exchange Quality Improvement Collaborative. Observational electronic health record data capturing telemedicine rates from 15 U.S.
View Article and Find Full Text PDFThis article describes the evolution of the Type 1 Diabetes Exchange Quality Improvement Collaborative (T1DX-QI) and provides insight into the development and growth of a successful type 1 diabetes quality improvement (QI) program. Since its inception 8 years ago, the collaborative has expanded to include centers across the United States with varying levels of QI experience, while simultaneously achieving many tangible improvements in type 1 diabetes care. These successes underscore the importance of learning health systems, data-sharing, benchmarking, and peer collaboration as drivers for continuous QI.
View Article and Find Full Text PDFFasting Serum IGFBP-1 as a Marker of Insulin Resistance in Diverse School Age Groups.
Front Endocrinol (Lausanne)
May 2022
Introduction: The known markers of insulin resistance in obese children are well studied. However, they require serial measurements and complicated calculations. The objective is to study IGFBP-1 and its relation with other known risk measures.
View Article and Find Full Text PDFContext: COVID-19 morbidity and mortality are increased in type 1 diabetes (T1D), but few data focus on age-based outcomes.
Objective: This work aimed to quantify the risk for COVID-19-related hospitalization and adverse outcomes by age in people with T1D.
Methods: For this observational, multisite, cross-sectional study of patients with T1D and laboratory-confirmed COVID-19 from 56 clinical sites in the United States, data were collected from April 2020 to March 2021.