Publications by authors named "S Aberami"
Copper mediates mitochondrial biogenesis in retinal pigment epithelial cells.
Biochim Biophys Acta Mol Basis Dis
October 2020
Age related macular degeneration (AMD) is a multifactorial disease with genetic, biochemical and environmental risk factors. We observed a significant increase in copper levels in choroid-RPE from donor eyeballs with AMD. Adult retinal pigment epithelial cells (ARPE19 cells) exposed to copper in-vitro showed a 2-fold increase in copper influx transporter CTR1 and copper uptake at 50 μM concentration.
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- * It involves 90 donor eyes (39 control and 51 with AMD) from a human eye bank, measuring levels of elements like lead, cadmium, chromium, and selenium using advanced technology.
- * Results show that AMD eyes had higher levels of certain metals and lower expression of oxidative stress-related genes, suggesting a link between heavy metal exposure, oxidative stress, and the development of AMD.
Early growth response-1 (Egr-1) protein upregulation is reported in diabetes and vascular disorders. This study aims at deciphering its role in hyperglycemia induced changes of retinal endothelium. Human retinal endothelial cells (hRECs) were exposed to hyperglycemia (25mM) and normoglycemia (5.
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