Background: Patients with microsatellite-instability-high (MSI-H) or mismatch-repair-deficient (dMMR) metastatic colorectal cancer have poor outcomes with standard chemotherapy with or without targeted therapies. Nivolumab plus ipilimumab has shown clinical benefit in nonrandomized studies of MSI-H or dMMR metastatic colorectal cancer.
Methods: In this phase 3 open-label trial, we randomly assigned patients with unresectable or metastatic colorectal cancer and MSI-H or dMMR status according to local testing to receive, in a 2:2:1 ratio, nivolumab plus ipilimumab, nivolumab alone, or chemotherapy with or without targeted therapies.
Dust particles, transported over long-distances and driven by westerly winds, dominate high-altitude (>4 km) snow darkening and melting over the Tibetan Plateau (TP). A systematic assessment of their remote sources and potential contributions remains limited. In this paper, we present a novel algorithm for source-tracing of airborne dust designed to tackle the aforementioned challenges.
View Article and Find Full Text PDFExpression of concern for 'Enhanced electrical and magnetic properties of (Co, Yb) co-doped ZnO memristor for neuromorphic computing' by Noureddine Elboughdiri , , 2023, , 35993-36008, https://doi.org/10.1039/D3RA06853F.
View Article and Find Full Text PDFThis work presents the first comprehensive assessment of PM pollution sources in Dushanbe, Tajikistan. A total of 138 PM samples were collected during 2015-2016 and 2018-2019 and were analyzed through gravimetric, ED-XRF, and multi-wavelength absorption techniques. The results show that PM concentrations were substantially higher than the European annual limit value and WHO Air Quality Guidelines annual average value, with an average of 90.
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