Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine.

CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR-associated proteins) has undergone marked advancements since its discovery as an adaptive immune system in bacteria and archaea, emerged as a potent gene-editing tool after the successful engineering of its synthetic guide RNA (sgRNA) toward the targeting of specific DNA sequences with high accuracy. Besides its DNA editing ability, further-developed Cas variants can also edit the epigenome, rendering the CRISPR-Cas system a versatile tool for genome and epigenome manipulation and a pioneering force in precision medicine. This review explores the latest advancements in CRISPR-Cas technology and its therapeutic and biomedical applications, highlighting its transformative impact on precision medicine.

Effects of Growth Stages on Leaf Nutrients, Metabolites, and Polyphenols of Three Varieties of Haskap.

Haskap ( L.) has gained much research interest, given the diverse biologically active compounds found in different parts of the plant. It is, therefore, important to study the concentration of some of these biologically active compounds at different developmental stages.

Seroepidemiological study of Neospora caninum in equids using c-ELISA in Erbil Province, Iraq.

Equine neosporosis is an intracellular protozoan disease with a global distribution, affecting a diverse range of warm-blooded animals. Neospora caninum Dubey, Carpenter, Speer, Topper et Uggla, 1988 is associated with foetal loss, neurological disease and abortion in equids. No information was available regarding equine N.

Evaluating the effectiveness of AI-powered UrologiQ's in accurately measuring kidney stone volume in urolithiasis patients.

Kidney stones and urolithiasis are kidney diseases that have a significant impact on health and well-being, and their incidence is increasing annually owing to factors such as age, sex, ethnicity, and geographical location. Accurate identification and volume measurement of kidney stones are critical for determining the appropriate surgical approach, as timely and precise treatment is essential to prevent complications and ensure successful outcomes. Larger stones often require more invasive procedures, and precise volume measurements are essential for effective surgical planning and patient outcomes.