Publications by authors named "S Abdelgani"
A look inside the gut as a clue to nutritional status.
Curr Opin Clin Nutr Metab Care
September 2024
Purpose Of Review: Malabsorption and malnutrition are common gastrointestinal manifestations clinicians face, requiring diagnostic workup for effective diagnosis and management of the underlying cause. This review discusses recent advances in diagnostic approaches to malabsorption and maldigestion of macronutrients - lipids, proteins, and carbohydrates. We highlight underrecognized causes, available testing modalities, and ongoing diagnostic unmet needs.
View Article and Find Full Text PDFObjective: To examine the effect of empagliflozin on liver fat content in individuals with and without type 2 diabetes (T2D) and the relationship between the decrease in liver fat and other metabolic actions of empagliflozin.
Research Design And Methods: Thirty individuals with T2D and 27 without were randomly assigned to receive in double-blind fashion empagliflozin or matching placebo (2:1 ratio) for 12 weeks. Participants underwent 75-g oral glucose tolerance testing and measurement of liver fat content with MRS before therapy and at study end.
Article Synopsis
- - The study aimed to assess how increased hepatic glucose production (HGP) affects plasma glucose levels in both diabetic and nondiabetic individuals when treated with empagliflozin.
- - A total of 70 participants were given either empagliflozin or a placebo, with measurements of HGP taken at the start and after 3 months of treatment, revealing that early increases in HGP were outweighed by glucose excretion, leading to reduced fasting plasma glucose (FPG).
- - After 3 hours, HGP exceeded urinary glucose excretion, causing a slight rise in plasma glucose that stabilized after 12 weeks, indicating a balance between these processes maintained FPG levels despite ongoing glucose loss through urine.
Background: Plasma levels of angiopoietin-like protein 8 (ANGPTL8) are regulated by feeding and they increase following glucose ingestion. Because both plasma glucose and insulin increase following food ingestion, we aimed to determine whether the increase in plasma insulin and glucose or both are responsible for the increase in ANGPTL8 levels.
Methods: ANGPTL8 levels were measured in 30 subjects, 14 with impaired fasting glucose (IFG), and 16 with normal fasting glucose (NFG); the subjects received 75g glucose oral Glucose tolerance test (OGTT), multistep euglycaemic hyperinsulinemic clamp and hyperglycaemic clamp with pancreatic clamp.
Objective: To examine the mechanisms responsible for the increase in glucose and ketone production caused by empagliflozin in patients with type 2 diabetes mellitus (T2DM).
Research Design And Methods: Twelve subjects with T2DM participated in two studies performed in random order. In study 1, endogenous glucose production (EGP) was measured with 8-h infusion of 6,6,D2-glucose.