Covalent modification of proteins at specific, predetermined sites is essential for advancing biological and biopharmaceutical applications. Site-selective labeling techniques for protein modification allow us to effectively track biological function, intracellular dynamics, and localization. Despite numerous reports on modifying target proteins with functional chemical probes, unique organic reactions that achieve site-selective integration without compromising native functional properties remain a significant challenge.
View Article and Find Full Text PDFCardiovascular disease is the primary cause of mortality worldwide, as stated by the World Health Organization. We utilized the red fluorescence emitted by copper nanoclusters (CuNCs) to detect cardiac Troponin T (cTnT). We designed a fluorescent probe to detect cTnT using an on-off-on technique.
View Article and Find Full Text PDFArch Insect Biochem Physiol
December 2024
The plant defense against insects is multiple layers of interactions. They defend through direct defense and indirect defense. Direct defenses include both physical and chemical barriers that hinder insect growth, development, and reproduction.
View Article and Find Full Text PDFSmall intestine neuroendocrine tumours (SI-NETs) are often diagnosed late with a UK median of 3 years and high misdiagnosis rates. Previous studies, largely based on patient surveys, offer little data on improving diagnosis. In 2017, the South Wales NET service underwent a nationally commissioned, systematic transformation, aiming to improve diagnosis through the development of a gastroenterology and surgical referral network, and education of these specialities.
View Article and Find Full Text PDFIntroduction: Stripe rust, caused by f. sp. , poses a significant threat to wheat quality and production worldwide.
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