Publications by authors named "S AMBERG"
Frequency-to-Place Mismatch and Cochlear Implant Outcomes by Electrode Type.
JAMA Otolaryngol Head Neck Surg
December 2024
Importance: Speech recognition outcomes with a cochlear implant (CI) are highly variable. One factor suggested to correlate with CI-aided speech recognition is frequency-to-place mismatch, or the discrepancy between the natural tonotopic organization of the cochlea and the electric frequency allocation of the CI electrodes within the patient's cochlea.
Objective: To evaluate the association between frequency-to-place mismatch and speech recognition outcomes in a large cohort of postlingually deafened adult CI users, while controlling for various clinical factors known to be associated with those outcomes.
Article Synopsis
- - Argentine hemorrhagic fever, caused by the Junín virus (JUNV), has a high mortality rate and currently relies on limited treatments like immune plasma, highlighting the need for new antiviral therapies.
- - The fusion inhibitor LHF-535 and nucleoside analog favipiravir have shown potential in combating arenaviral infections, but using favipiravir alone requires high doses for effectiveness against JUNV.
- - Combining LHF-535 with a lower dose of favipiravir in guinea pig models resulted in complete protection from JUNV, demonstrating the potential of this drug combination to broaden treatment options and prevent drug resistance.
Article Synopsis
- Discordance between receptor expressions in metastatic brain lesions and primary tumors in breast cancer patients shows the need for personalized therapy through constant monitoring of these expressions.
- This study investigates using machine learning on MR imaging features to predict receptor status in brain metastases, analyzing 412 samples from 106 patients over a 14-year period.
- Results reveal that MR image features can accurately predict the receptor status (ER+, PR+, HER2+) with high discriminatory accuracy, suggesting a valuable tool for individualized treatment planning.
Background & Aims: Machine perfusion is a novel method intended to optimize livers before transplantation. However, its effect on morbidity within a 1-year period after transplantation has remained unclear.
Methods: In this multicenter controlled trial, we randomly assigned livers donated after brain death (DBD) for liver transplantation (LT).
Relapse in patients with acute myeloid leukemia (AML) is common and is associated with a dismal prognosis. Treatment options are limited and the understanding of molecular response patterns is still challenging. We analyzed the clonal response patterns of 15 patients with relapsed/refractory AML treated with selinexor in a phase II trial (SAIL).
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