Correlation of nucleotides and carbohydrates metabolism with pro-oxidant and antioxidant systems of erythrocytes depending on age in patients with colorectal cancer.

Aim: To examine the relationship between metabolic features of purine nucleotides and antioxidant system depending on the age of patients with colorectal cancer.

Materials And Methods: The activity of adenosine deaminase, xanthine oxidase, glutathione peroxidase, superoxide dismutase and glucose-6-phosphate dehydrogenase, the NOx concentration and the oxidative modification of proteins were determined spectrophotometricaly in 50 apparently healthy people and 26 patients with colorectal cancer stage -III---IV, aged 40 to 79 years.

Results: Increase of pro-oxidant system of erythrocytes with the age against decrease in level of antioxidant protection in both healthy individuals and colorectal cancer patients was determined.

[Metabolism of nucleotides and its inter-relation with pro-oxidant and antioxidant systems in people of different age ranges].

The interrelation of purine nucleotides with antioxidant system in blood plasma and erythrocytes depending on age, as well as the contribution of the key enzymes of purine decomposition to the formation of reactive oxygen metabolites were studied. 50 conditionally healthy people aged 40-79 years were examined. Increase in all indicators of pro-oxidant system of blood plasma with age was determined.