Publications by authors named "S A Vinogradov"
Bone fracture ruptures blood vessels and disrupts the bone marrow, the site of new red blood cell production (erythropoiesis). Current dogma holds that bone fracture causes severe hypoxia at the fracture site, due to vascular rupture, and that this hypoxia must be overcome for regeneration. Here, we show that the early fracture site is not hypoxic, but instead exhibits high oxygen tension (> 55 mmHg, or 8%), similar to the red blood cell reservoir, the spleen.
View Article and Find Full Text PDFTwo-photon phosphorescence lifetime microscopy has been a key tool for studying cerebral oxygenation in mice. However, the accuracy of the partial pressure of oxygen (pO) measurements is affected by out-of-focus signal. In this work, we applied reconfigurable differential aberration imaging to characterize and correct for out-of-focus signal contamination in intravascular pO imaging.
View Article and Find Full Text PDFPutting measurement-based care into action: a multi-method study of the benefits of integrating routine client feedback in coordinated specialty care programs for early psychosis.
BMC Psychiatry
December 2024
Article Synopsis
- Measurement-based care (MBC) enhances evidence-based practices (EBPs) by providing personalized feedback reports to clients and clinicians, particularly for young people with early psychosis.
- A study evaluated these feedback reports at five specialty care programs, comparing outcomes for clients who received reports versus those who did not over their first six months of treatment.
- Results indicated improvements in decision-making and treatment engagement among clients receiving feedback, with they participating more in supportive services, although overall statistical significance was not achieved.
Purpose: This study aimed to assess the impact of tissue oxygen levels on transient oxygen consumption induced by ultra-high dose rate (UHDR) electron radiation in murine flank and to examine the effect of dose rate variations on this relationship.
Methods And Materials: Real-time oximetry using the phosphorescence quenching method and Oxyphor PdG4 molecular probe was employed. Continuous measurements were taken during radiation delivery on a UHDR-capable Mobetron linear accelerator.
Article Synopsis
- Coordinated specialty care (CSC) programs in the U.S. focus on treating first episodes of psychosis and involve engaging the patient's family in the treatment process, though the effects of this engagement are not well-studied.
- The study compared two groups of clients—those with family engagement and those without—examining their demographics, treatment visits, and self-reported intentions regarding treatment continuity and medication adherence over the first six months.
- Findings indicated that family-engaged clients were generally younger and had different racial demographics; engagement led to more treatment visits and increased intent to attend but did not significantly impact medication adherence. Both groups showed high rates of adherence.