Publications by authors named "S A Vandenberg"
Only a subset of patients with breast cancer responds to immune checkpoint blockade (ICB). To better understand the underlying mechanisms, we analyze pretreatment biopsies from patients in the I-SPY 2 trial who receive neoadjuvant ICB using multiple platforms to profile the tumor microenvironment. A variety of immune cell populations and markers of immune/cytokine signaling associate with pathologic complete response (pCR).
View Article and Find Full Text PDFAim: To map the extent of the use of the term 'planetary health' in peer-reviewed nursing literature.
Design: Scoping Review.
Data Sources: CINAHL, ProQuest Nursing & Allied Health Premium, MEDLINE, APA PsycINFO, ProQuest Dissertations & Theses and Web of Science were searched in January and February 2024 for English and French-language publications.
Article Synopsis
- One third of organ donors experience catastrophic brain injury (CBI), but there’s no standardized management for traumatic CBI among trauma centers, leading to variability in practices.
- A multicenter trial involving 33 trauma centers analyzed 790 CBI patients to investigate whether institutions with CBI guidelines had higher organ donation rates.
- While centers with CBI guidelines showed greater use of certain treatments, the presence of guidelines did not significantly increase organ donation rates; however, hormone therapies were linked to a higher likelihood of donation.
Article Synopsis
- This study outlines a protocol for a systematic review focused on how to manage methamphetamine intoxication, particularly in terms of violence and agitation in emergency departments.
- The review will evaluate various pharmacological and non-pharmacological treatments for patients exhibiting violent behavior due to methamphetamine use and examine their effectiveness on de-escalation time, length of stay, admission rates, and provider satisfaction.
- Ethical approval has been secured for the study, and findings will be published in a peer-reviewed journal and shared at healthcare conferences in Canada.