The integration of numerical simulations with Liver-on-a-Chip (LoC) technology offers an innovative approach for studying liver physiology and pathology, especially in the context of liver cancer. Numerical simulations facilitate the optimization of microfluidic devices' design and deepen the understanding of fluid flow and mass transfer. However, despite significant advancements, challenges such as replicating the full complexity of the liver microenvironment and scaling up for high-throughput screening persist.
View Article and Find Full Text PDFC57BL/6 mice, orally infected with T. gondii, experience pronounced severe intestinal inflammation, causing necrosis, weight loss, and bacterial translocation. In addition, immunomodulatory molecules such as lipocalins, nitrophorins, and apyrases are present in R.
View Article and Find Full Text PDFToxoplasmosis is an alarming public health problem that affects more than one-third of the world's population. In our work, we investigated the antiparasitic effects of catalytically active [BpMP-I and Jararhagin (Jar)] and catalytically inactive [Jararhagin-C (Jar-C)] snake venom metalloproteinases (SVMPs) in human HeLa cells. These toxins impaired the parasite invasion and intracellular growth, and modulated IL-6, IL-8, and MIF cytokines that control the cell susceptibility and response against .
View Article and Find Full Text PDFBackground And Purpose: Subpial hemorrhage is an underrecognized type of hemorrhagic stroke primarily affecting neonates. Blood accumulation in the impermeable pia mater compresses the adjacent cortex, leading to injury. The consequences of this stroke type remain poorly understood.
View Article and Find Full Text PDFThis study aims to develop and validate a novel fast-detection electrochemical sensing platform to enhance portable electrochemical sensor solutions. The research focuses on optimising analogue front-end circuits, developing data analysis algorithms, and validating the device through experiments to enhance measurement accuracy and detection speed, enabling on-site measurements across diverse applications. This work successfully designed a Portable Unit for Lab-on-Site Electrochemistry (PULSE) system with dimensions of (78×100×2) mm3.
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