Publications by authors named "S A Tauber"
Introduction: To report a series of patients who developed ocular surface disease related to tisotumab vedotin-tftv (TV), an antibody-drug conjugate (ADC) approved for the treatment of recurrent or metastatic cervical cancer.
Methods: This was a multicenter retrospective chart review study of patients who developed ocular surface disease related to TV between April 1st, 2022 to August 31st, 2023.
Results: Five patients were identified who developed ocular surface disease while on TV.
Background: The brain is protected from invading pathogens by the blood-brain barrier (BBB) and the innate immune system. Pattern recognition receptors play a crucial role in detecting bacteria and initiating the innate immune response. Among these are G-protein-coupled formyl peptide receptors (FPR), which are expressed by immune cells in the central nervous system.
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- In vitro reconstructed minimal respiratory chains are used to study how enzyme components interact within their environment, particularly focusing on the coreconstitution of cytochrome oxidase and ATP synthase in liposomes.
- The study explores using natural long-chain ubiquinone and various electron donors like succinate or NADH, while revealing that negatively charged lipids are necessary for effective enzyme activity but also reduce ATP synthesis rates.
- To optimize enzyme orientation and ATP production, researchers utilize ionizable lipids that can switch charges based on pH, successfully enhancing ATP synthesis rates by aligning cytochrome oxidase for better function with NDH-2.