Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation.

Bisacodyl is a widely used laxative that stimulates both motility and secretion. Our aim was to exploit the unique capabilities of MRI to define bisacodyl's mode of action. Two placebo-controlled cross-over trials were performed, one using a single dose of Bisacodyl 5 mg while the second dosed daily for 3 consecutive days.

Exploring the mechanisms underlying recovery from freeze-thaw injury in Colobanthus quitensis: mechanistic insights via transcriptome profiling.

Antarctic plants face significant challenges due to exposure to freeze-thaw stress throughout their life cycle. The ability to recover from freeze-thaw injuries during post-thaw recovery (PTR) periods is a crucial skill for their survival and growth. However, no research, to the best our knowledge, has explored their recovery mechanisms at the cellular and molecular levels.

The regulatory effects of mitragynine on P-glycoprotein transporter.

Objectives: Kratom preparation containing Mitragyna speciosa Korth plant is frequently used as a recreational drug. Mitragynine, a major alkaloid isolated from M. speciosa, is often detected concurrently with other drugs during forensic analysis, indicating a safety concern.