Publications by authors named "S A Stocker"
Risk of bias tools for medication adherence research: RoBIAS and RoBOAS.
Br J Clin Pharmacol
January 2025
Aims: An unbiased means of documenting medication-taking is important to ensure quality evidence about adherence research and to accurately identify individuals at risk of suboptimal adherence for the development of targeted and effective interventions. Guidance to assist researchers in the understanding of risk of bias when conducting or reviewing adherence research is currently not available. To address this gap, tools to identify and gauge the magnitude of important biases that may impact adherence research have been developed.
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- The study focuses on the patterns of medication adherence among gout patients using allopurinol and how these patterns affect serum urate levels and clinical outcomes.
- It finds that while occasional missed doses may not drastically impact urate control, consistently taking breaks of more than three days significantly lowers the likelihood of achieving adequate urate levels.
- The research emphasizes the importance of understanding individual medication-taking habits to improve treatment outcomes for gout patients.
Introduction: Pyrazinamide, one of the first-line antituberculosis drugs, displays variability in drug exposure that is associated with treatment response. A simple, low-cost assay may be helpful to optimize treatment. This study aimed to develop and validate a point-of-care assay to quantify the concentration of pyrazinamide in saliva.
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- * The study analyzed data from 258 gout patients and found that increased oxypurinol exposure is necessary for effective urate reduction in those with decreased kidney function or on diuretics, despite lower overall dose requirements at severe kidney impairment.
- * Ultimately, the research concluded that patients with significant kidney impairment need lower allopurinol doses, but these doses do not directly correlate with kidney function, and diuretics do not affect required doses.