Comparing the incidence of hypospadias across the United States: A contemporary analysis.

Introduction: Hypospadias is a common congenital malformation occurring in up to 80 in 10,00 live male births, with emerging evidence associating exogenous environmental exposures with increased disease incidence. Military personnel are at particularly higher risk for such exposures and indeed, the rate of hypospadias in infant males born to United States military servicewomen deployed during the Gulf War has been reported to be more than 5 times greater compared to undeployed female military personnel.

Objective: To characterize contemporary trends in hypospadias incidence in the general population as well as high risk groups such as males born from US servicewomen using the National Birth Defects Prevention Network.

Clinical modeling of motor function to predict treatment efficacy and enable in silico treatment comparisons in infantile-onset Pompe disease.

Infantile-onset Pompe disease (IOPD) is a rare, deadly, quickly-progressing degenerative disease. Even with life-sustaining treatment (e.g.

The Magnitude of the Blood Acid-Base Response, but Not Time to Peak, Is Reliable Following the Ingestion of Acute, Individualized Sodium Citrate.

Enhanced buffering capacity following sodium citrate (SC) ingestion may be optimized when subsequent exercise commences at individual time-to-peak (TTP) alkalosis (blood pH or bicarbonate concentration [HCO3-]). While accounting for considerable interindividual variation in TTP (188-300 min), a reliable blood alkalotic response is required for practical use. This study evaluated the reliability of blood pH, HCO3-, and sodium (Na+) following acute SC ingestion.

Heat resistance differences are common between both vegetative cells and spores of type F isolates carrying a chromosomal vs plasmid-borne enterotoxin gene.

type F isolates utilize enterotoxin (CPE) to cause food poisoning (FP) and nonfoodborne gastrointestinal diseases. The enterotoxin gene () can be located on either the chromosome or plasmids, but most FP isolates carry a chromosomal (c) gene. Our 2000 article in (66:3234-3240, 2000, https://doi.