[Clinicomorphological changes of liver in atherogenic dyslipidemia and after treatment with statins].

Aim: To evaluate clinicofunctional and morphological changes in the liver of patients with atherogenic dyslipidemia and in the course of treatment with statins.

Material And Methods: A general clinical examination, biochemical hepatic tests, determination of blood lipid spectrum, markers of viral hepatites B, C, G, TT, ultrasound hepatic imaging of the liver of bile ducts, punch biopsy of the liver were made in 60 patients (38 females and 22 males) at the age of 39 to 70 years with atherogenic dyslipidemia (ADL).

Results: Biochemical tests showed high activity of transaminases (1.

[Changes in the liver in glutenic enteropathy].

Aim: To evaluate frequency of clinical manifestations, biochemical and morphological alterations characteristic of liver affection in patients with glutenic enteropathy (GEP) in correlation with GE duration and severity of malabsorption syndrome (MAS).

Material And Methods: 116 GEP patients have undergone clinico-laboratory examination, intestinoscopy with biopsy of jejunal mucosa, puncture biopsy of the liver with morphological examination of the specimens, ultrasonography of the liver. In addition, the immune status was assessed and tests for markers of hepatotropic viruses B and C were made.

[Primary biliary cirrhosis: 12-year experience in observation].

Aim: To ascertain initial signs of primary biliary cirrhosis (PBC), criteria of its early diagnosis, variants of the course, clinical picture and life quality of PBC patients.

Material And Methods: 128 PBC patients were examined in the Central Research Institute of Gastroenterology from 1991 to 2002. Quality of life was assessed by SF-36 questionnaire adapted for patients with chronic cholestatic diseases of the liver.

[Clinico-morphological changes of the liver in patients with dyslipoproteinemia].

At present the disorders of lipid metabolism and connected diseases are studied insufficiently. Some disorders with the basis of lipid metabolism disorders are combined into the lipid distress-syndrome. The clinical study of 60 patients with expressed dislipoproteidemia (48 female and 12 male) in the age 46-79 years were made by the clinical observation, estimation of biochemical indexes, lipid blood spectrum, viral hepatitis markers, ultrasonic and liver biopsy.