The size principle is a key mechanism governing the orderly recruitment of motor units and is believed to be dependent on passive properties of the constituent motoneurons. However, motoneurons are endowed with voltage-sensitive ion channels that create non-linearities in their input-output functions. Here we describe a role for the M-type potassium current, conducted by KCNQ channels, in the control of motoneuron recruitment in mice.
View Article and Find Full Text PDFThe intensity of muscle contraction, and therefore movement vigor, needs to be adaptable to enable complex motor behaviors. This can be achieved by adjusting the properties of motor neurons, which form the final common pathway for all motor output from the central nervous system. Here, we identify roles for a neuropeptide, cocaine- and amphetamine-regulated transcript (CART), in the control of movement vigor.
View Article and Find Full Text PDFThis study conducted an experimental analysis of how indoor air quality (IAQ) is influenced by the outdoor air pollutants levels, infiltration rate, and occupants' behaviours. The impacts of these factors on IAQ were analyzed using on-site measurements and numerical simulations. The results contribute to a better understanding of how to control the Indoor Particulate Level (IPL) for the specific conditions of the studied building.
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