Unveiling Cathepsin B inhibition with repurposed drugs for anticancer and anti-Alzheimer's drug discovery.

Alzheimer's disease (AD) is characterized by the aggregation of amyloid β (Aβ) peptides and the formation of plaques in the brain, primarily derived from the proteolytic degradation of amyloid precursor protein (APP). Cathepsin B (CatB) is a cysteine protease that plays a pivotal role in this process, making it a potential target for the development of anti-Alzheimer's therapies. Apart from AD, CatB is implicated in various physiological and pathological processes, including cancer.

Repurposed drugs as histone deacetylase 8 inhibitors: Implications in cancer and neuropathological conditions.

Histone deacetylase 8 (HDAC8) is a member of class I histone deacetylases (HDACs) that catalyzes the deacetylation of both histone and non-histone proteins. Dysregulation and overexpression of HDAC8 are implicated in the development of various complex diseases, including cancer and neurodegenerative disorders. HDAC8 plays a significant role in cancer progression, contributing to cancer cell proliferation, metastasis, immune evasion, and drug resistance.

Automated brain tumor recognition using equilibrium optimizer with deep learning approach on MRI images.

Brain tumours (BT) affect human health owing to their location. Artificial intelligence (AI) is intended to assist in diagnosing and treating complex diseases by combining technologies like deep learning (DL), big data analytics, and machine learning (ML). AI can identify and categorize tumours by analyzing brain imaging approaches like Magnetic Resonance Imaging (MRI).

Perceptions of Artificial Intelligence in Medicine Among Newly Graduated Interns: A Cross-Sectional Study.

Background Artificial intelligence (AI) is rapidly transforming the healthcare sector, enhancing clinical decision-making, improving patient outcomes, and streamlining operations. Despite its promise, the integration of AI raises important questions about ethical considerations, data privacy, and implications for healthcare professionals. Methods This cross-sectional study utilized an online survey to assess the perceptions of newly graduated interns applying to post-graduate programs under the Saudi Commission for Health Specialties.