Effect of p-nitromethylamphetamine on biogenic amines and their amino-acid precursors in rat brain.

1. Low doses of p-nitromethylamphetamine caused small increases in the concentrations of brain noradrenaline and dopamine in the rat; a dose of 60 mg/kg however, caused a decrease in the concentrations of both amines. p-Nitromethylamphetamine caused behavioural hyperexcitability only at doses which approximated to half the LD50 (68 mg/kg).

Some neurochemical effects of amphetamine, methylamphetamine and p-bromomethylamphetamine in the rat.

1. Low doses of D-amphetamine increased brain noradrenaline concentrations in the rat; doses greater than 5 mg/kg, however, caused a decrease. Methylamphetamine also showed this dual effect, but a reduction in brain noradrenaline concentration only occurred when doses greater than 10 mg/kg were administered.