Comparison of differential protein expression of the marginal transitional zone in neonatal and weanling-aged foals.

The marginal transitional zone (MTZ) is peripherally located within the diarthrodial joint, and represents the junction of synovium, fibrous joint capsule, articular cartilage, periosteum, and bone. The purpose of this study is to characterize age-related differences in protein expression of matrix and molecular regulators in the marginal transitional zone of neonatal and weanling foals. Several families of proteins with known roles in cartilage and bone development are investigated, including matrix molecules, members of the Wnt signaling family, apoptotic factors and paracrine cell signaling molecules.

Role of cartilage and bone matrix regulation in early equine osteochondrosis.

The objective of this study is to better understand the pathogenesis of early equine osteochondrosis (OC) by identifying differences in gene and protein expression of extracellular matrix components and regulators in normal and diseased cartilage and bone, focusing on the osteochondral junction and cells surrounding the cartilage canals. We expected to find an upregulation of matrix metalloproteinases and a decrease in extracellular matrix constituent expression along the osteochondral junction and cells surrounding the cartilage canals in OC samples. Paraffin-embedded osteochondral samples (6 OC-affected, 8 normal controls) and cDNA from chondrocytes captured with laser capture microdissection from frozen sections (4 OC-affected, 5 normal controls) were used in this study.

Differential Protein Expression of the Marginal Transitional Zone in Foals with Osteochondrosis.

The marginal transitional zone is peripherally located within the diarthrodial joint, and represents the interface of articular cartilage, periosteum, and the fibrous joint capsule. The purpose of this study is to characterize the protein expression of matrix and molecular regulators in the marginal transitional zone of foals having osteochondrosis (OC) compared to normal foals. Several families of proteins with known roles in cartilage and bone development are investigated, including matrix molecules, Wnt signaling, apoptotic factors and paracrine cell signaling molecules.

Outcome of bilateral equid laparoscopic ovariectomies.

Objective: To assess outcomes and behavior changes associated with bilateral laparoscopic ovariectomies.

Study Design: Retrospective study.

Sample Population: Fifty-one equids.

Muscle tears as a primary cause of lameness in horses: 14 cases (2009-2016).

This study describes clinical and ultrasonographic findings and outcomes of horses with lameness associated with muscle tears. Records of horses diagnosed with muscle tears were retrospectively evaluated. Horses in which one or more muscle tears were confirmed ultrasonographically and lameness was associated with the tear were included in the study ( = 14).