Publications by authors named "S A Seaman"
Background: An increasing number of patients with pulmonary arterial hypertension (PAH) have cardiovascular comorbidities. However, the effects of comorbidities on responses to PAH treatment are not well understood.
Research Question: Do cardiovascular comorbidities in patients with PAH influence the efficacy and tolerability of inhaled or oral treprostinil?
Study Design And Methods: All patients from phase 3 studies TRIUMPH (N = 235) and FREEDOM-EV (N = 690) were included in this post hoc analysis and were classified as having 0, ≥1, or ≥2 cardiovascular comorbidities of interest based on patients' medical histories.
Marginal structural models (MSMs) are often used to estimate causal effects of treatments on survival time outcomes from observational data when time-dependent confounding may be present. They can be fitted using, for example, inverse probability of treatment weighting (IPTW). It is important to evaluate the performance of statistical methods in different scenarios, and simulation studies are a key tool for such evaluations.
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- Previous studies showed limited evidence on how buprenorphine versus methadone affects different groups of people using opioids, particularly with the rise of fentanyl use.
- The study aimed to compare the risks of treatment discontinuation and mortality between individuals using buprenorphine/naloxone versus those using methadone for opioid use disorder in British Columbia from 2010 to 2020.
- Findings revealed that users of buprenorphine/naloxone had a significantly higher likelihood of discontinuing treatment after 24 months compared to those on methadone, with 88.8% versus 81.5% discontinuing, indicating that methadone may be more effective in retaining users.
Article Synopsis
- The study assessed the effectiveness of bivalent and monovalent mRNA COVID-19 boosters among UK healthcare workers from October 2023 to March 2024 during the circulation of the XBB.1.5 and JN.1 variants.
- Among 2867 participants, about half received a booster, and 19% experienced confirmed infections; the monovalent booster showed better effectiveness compared to the bivalent one, especially in the first two months post-vaccination.
- Results indicated that recent infections boosted immunity, and the findings suggest that tailored vaccines for circulating variants could be beneficial for seasonal immunization among healthcare workers.
Impact of Previous Surgery and/or Radiation Therapy on Endoscopic Reconstruction Outcomes.
Oper Neurosurg (Hagerstown)
August 2024
Background And Objectives: The impact of prior local therapies, including radiation and surgery, on reconstruction outcomes after endonasal surgery is currently not well known. Reconstruction nuances in the preoperative setting merit further evaluation to avoid potential postoperative complications that can hinder overall tumor management and negatively impact patient outcome. We sought to determine whether prior treatments increase risk of reconstruction-related postoperative morbidity and to evaluate the effectiveness of our current treatment paradigm for skull base reconstruction.
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