Publications by authors named "S A Schoenrock"
Article Synopsis
- The MiniMUGA genotyping array is a widely used tool for ensuring genetic quality control in laboratory mice and for genotyping various experimental crosses, particularly those of reduced complexity.
- Recent efforts have focused on enhancing the performance of the MiniMUGA array by improving marker annotation and increasing the reliability and number of consensus genotypes for inbred strains and substrains.
- Key updates to the informatics pipeline and report layout aim to simplify data interpretation and enhance overall utility, promoting better rigor and reproducibility in mouse-based biomedical research.
Unlabelled: Much is known regarding the major white matter pathways connecting the right and left temporal lobes, which project through the posterior corpus callosum, the anterior commissure, and the dorsal hippocampal commissure. However, details about the spatial location of these tracts are unclear, including their exact course and proximity to cortical and subcortical structures, the spatial relations between corpus callosum and anterior commissure projections, and the caudal extent of transcallosal connections within the splenium. We present an atlas of these tracts derived from high angular resolution diffusion tractography maps, providing improved visualization of the spatial relationships of these tracts.
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- Emerging evidence suggests that liver disease may begin in development due to high genome plasticity and the establishment of liver function pathways.
- A study using a Collaborative Cross mouse model with developmental vitamin D deficiency (DVD) explored how DVD disrupts liver gene expression and metabolism, factoring in the impact of parental origin of the genome (POG).
- Results showed that DVD significantly affected liver gene expression, reducing genes related to liver development and energy production, with distinct responses observed between different POGs, particularly in gene expression and metabolic profiles related to energy utilization.
Article Synopsis
- Cocaine use and related overdose deaths have dramatically increased in the U.S. over the past decade, yet there are no approved medications for cocaine use disorder (CUD) due to limited understanding of its causes.
- Genetic factors are known to play a role in CUD risk, but current research has identified very few relevant genes, primarily using studies in mice which lack genetic diversity.
- A new study used a comprehensive 19-day protocol to measure cocaine-induced behaviors across 51 genetically diverse mouse strains, revealing significant differences in sensitivity and sensitization to cocaine, which can help identify the genetic basis of addiction and aid in future research.
Article Synopsis
- * Traditional genetic mapping in addiction research has identified many chromosomal regions but often fails to pinpoint the exact causal genes.
- * This study examines 20 inbred mouse substrains to observe differences in cocaine-induced locomotor activation, paving the way for new research strategies to identify specific genetic factors linked to addiction.