[The efficacy of specific plasma in the therapy of newborn infants with a Pseudomonas aeruginosa surgical infection].

141 newborn with purulent surgical infection were under observation. In 73 the inflammatory process was not induced by Pseudomonas aeruginosa in 68 the infection was caused by the blue pus bacillus. Bacteriological and immunological examination was conducted, including that with the use of enzyme immunoassay, to monitor the optical density of anti-pyocyanea antibodies during the course of the disease.

[Immunologic correction in the treatment of chronic hematogenic osteomyelitis of long tubular bones in children].

Children suffering from chronic osteomyelitis of long tubular bones were compared for the action of the immunomodulating drug tactivin injected subcutaneously and endolymphatically. The study was carried out in 57 patients staying in hospital. The patients were distributed into the following groups: 18 patients entered a group where tactivin was injected subcutaneously, 9 patients made up a group where the drug was administered endolymphatically, and a reference group included 30 patients treated by conventional methods.

[Endolymphatic therapy of children with chronic osteomyelitis of the long tubular bones].

A study was made of the clinical efficacy and immune status in 40 children with chronic osteomyelitis of long tubular bones. Of these, 13 patients received antibiotics endolymphatically and 27 patients were given conventional antibiotic therapy (intramuscularly, intravenously). In view of the predominance of the staphylococcal flora, endolymphatic therapy included the use of gentamycin and lincomycin, the treatment course lasted up to 10 days.

[Immunologic disorders in children with developmental thoracic defects].

As the result of immunological examination of 21 children with developmental defects of the chest and analysis of the course of the postoperative period in 136 children, among which 36 had hereditary syndromes of systemic connective-tissue dyshistogenesis, it was found that suppurative complications of thoracoplasty, which are encountered in 15% of children with isolated developmental chest defects and in 33.3% of those with the above mentioned syndromes, were caused to a great measure by disorders of the immune status. The most serious immunological deviations were encountered in the Marfan syndrome due to impaired phagocytic activity of neutrophils and monocytes, decreased number of T, T active, and B lymphocytes, and diminished function of T helpers.

The effect of using T-activin in the therapy of the newborn with suppurative surgical infection.

A total of 156 newborn infants with suppurative surgical infection (SSI) were observed; 73 of them had sepsis and 83 a severe localized process. In 47 patients with sepsis and 34 with localized infection, T-activin was included in complex therapy while the other infants formed the control group. It has been established that T-activin leads to an increase in the quantity of the active population of T-lymphocytes in the peripheral blood and to enhanced functional activity of T-lymphocytes in the newborn with SSI independent of generalization of the process.