Exploring farmers' psychological perspectives on multimedia-based agro-advisory services.

Agro-advisory through multimedia plays a crucial role for improving farmers' access to information and serves as a ready reckoner for the stakeholders to make better and informed decisions. Although there is existing research on multimedia-based agro-advisory services (MAS), there remains a significant gap in understanding the psychological factors that affect their usage behaviour (UB), especially among agricultural stakeholders. This demands further investigation through region-specific studies to comprehensively address this gap and devise target-based interventions for their uptake.

Monitoring Molecular Interactions with Cell Membranes Using Time-Dependent Second Harmonic Generation Microscopy.

Time-resolved second harmonic generation (SHG) microscopy is used to investigate the physicochemical interactions between positively charged, hydrophobic, drug-like molecules and the plasma membrane of human cells (nonsmall cell lung cancer, H596). In the present study, molecular adsorption and transport of the cationic molecules, malachite green (MG) and malachite green isothiocyanate (MGITC), are studied in real time in living H596 cells and in dead, fixed H596 cells. MGITC is shown to have stronger adsorption and more rapid transport kinetics as compared to MG due to increased dipole-dipole interactions.

CLINICAL utility of assessing CDKN2A status in recurrent astrocytomas.

IDH-mutant astrocytomas exhibit a more indolent natural history and better prognosis compared to their IDH-wild type counterparts. WHO 2021 classification integrated CDKN2A/B homozygous deletion as a crucial criterion for grading these tumors, emphasizing its prognostic implications. FISH assay is commonly used to assess CDKN2A status, but guidelines for interpreting FISH results for glioma prognostication are not well-defined in the literature.

Complete Valorization of Cashew Nutshell Waste Enriched with Sulfur Copolymer for Efficient Mercury Removal.

Integrating sustainable raw materials with efficient synthesis is key to advancing eco-friendly solutions. Renewable feedstocks like cashew nutshells (CNS) and elemental sulfur, an industrial byproduct, are underutilized resources. This study presents a simple method to valorize CNS and sulfur, creating a copolymer composite designed for efficient mercury removal from contaminated water.

Emerging Role of Natural Topoisomerase Inhibitors as Anticancer agents.

Topoisomerases I and II are the functionally two forms of DNA topoisomerase. In anticancer research, novel anticancer chemotherapeutical capable of blocking topoisomerase enzymes have been discovered. Most commonly, topoisomerase causes replication fork arrest and doublestrand breaks, and this is how a clinically successful topoisomerase-targeting anticancer medicines work.