Publications by authors named "S A Sabbagh"
Neurotrophins are proteins that mediate neuronal development using spatiotemporal signaling gradients. The chicken nucleus magnocellularis (NM), an analogous structure to the mammalian anteroventral cochlear nucleus, provides a model system in which signaling between the brain-derived neurotrophic factor (BDNF) and tyrosine receptor kinase B (TrkB) is temporally regulated. In the NM, TrkB expression is high early in development (embryonic [E] day 9) and is downregulated until maturity (E18-21).
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- Juvenile dermatomyositis (JDM) is a common inflammatory muscle disease in children that still causes significant health issues despite improvements in treatment.
- Different clinical types of JDM are linked to specific myositis-related antibodies, suggesting a correlation between the disease's manifestations and underlying biology.
- The paper discusses how combining clinical observations with molecular analysis can inform more effective targeted therapies by understanding the role of immune pathways in JDM.
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- * Thirty male Wistar rats were used in the experiment, divided into groups receiving either gentamicin, beta-carotene, both, or control treatments, with tests done on serum and tissues to evaluate hepatorenal function.
- * Results showed that beta-carotene significantly reduced markers of liver and kidney damage (like SGOT, SGPT, creatinine, and urea levels) compared to gentamicin alone, suggesting it may be beneficial as an additional treatment for patients receiving gentamicin.
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- A study evaluated the safety and efficacy of endovascular thrombectomy in patients with acute large-vessel occlusion and tandem lesions, focusing on those with low (0-5) and high (6-10) Alberta Stroke Program Early Computed Tomography Scores (ASPECTS).
- The analysis included 691 patients, revealing that those with low ASPECTS had significantly lower odds of achieving a favorable functional outcome (mRS 0-2) and higher odds of suffering symptomatic intracranial hemorrhage compared to those with high ASPECTS.
- The researchers concluded that endovascular thrombectomy may lead to poorer functional recovery in patients with tandem lesions and low ASPECTS, particularly in the
Article Synopsis
- Internal organ development in embryos involves the process of cell internalization, which can happen individually or collectively, with epithelial invagination being a well-studied method.
- The study focuses on the Drosophila embryo, specifically the anterior midgut primordium, revealing that an epithelial-mesenchymal transition (EMT) happens during its internalization while still at the surface.
- The findings suggest that this process of collective EMT aids in the primordium's internalization through both cell divisions and the movement of cells, supported by the remodeling of adjacent tissues.