Publications by authors named "S A Rocco"
Isatuximab, a novel anti-CD38 monoclonal antibody, is approved in combination with carfilzomib and dexamethasone (Isa-Kd) in relapsed/refractory multiple myeloma (RRMM) patients. Because of its recent introduction, real-world efficacy and safety are poorly reported. In this Italian multicenter real-life observational retrospective study, efficacy and safety of the Isa-Kd regimen were evaluated in a cohort of 103 RRMM patients.
View Article and Find Full Text PDFBreast cancer (BC) remains a significant global health concern, with neoadjuvant chemotherapy (NACT) offering preoperative benefits like tumor downstaging and treatment response assessment. However, identifying factors influencing post-NACT treatment response and survival outcomes is challenging. Metabolomic approaches offer promising insights into understanding these outcomes.
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- - Propolis, a complex resin produced by bees, varies in composition based on the plants the bees visit, and red Brazilian propolis shows promising antimicrobial properties that need further investigation.
- - This study aimed to refine a method to efficiently extract and isolate beneficial compounds from red propolis using counter-current chromatography and preparative HPLC, addressing issues like wax removal that can clog equipment.
- - The researchers successfully isolated three key compounds linked to red propolis's therapeutic effects, identifying them as retusapurpurin A, 3()-7-O-methylvestitol, and xanthochymol/isoxanthochymol, which will aid in future biological testing and serve as standards in chromatography.
Macrophage (Mφ) plasticity is critical for normal wound repair; however, in type 2 diabetic wounds, Mφs persist in a low-grade inflammatory state that prevents the resolution of wound inflammation. Increased NLRP3 inflammasome activity has been shown in diabetic wound Mφs; however, the molecular mechanisms regulating NLRP3 expression and activity are unclear. Here, we identified that diabetic wound keratinocytes induce Nlrp3 gene expression in wound Mφs through IL-1 receptor-mediated signaling, resulting in enhanced inflammasome activation in the presence of pathogen-associated molecular patterns and damage-associated molecular patterns.
View Article and Find Full Text PDFBalloon venoplasty is a commonly used clinical technique to treat deep vein stenosis and occlusion as a consequence of trauma, congenital anatomic abnormalities, acute deep vein thrombosis (DVT), or stenting. Chronic deep venous obstruction is histopathologically characterized by thrombosis, fibrosis, or both. Currently, no direct treatment is available to target these pathological processes.
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