Preclinical use of a clinically-relevant scAAV9/SUMF1 vector for the treatment of multiple sulfatase deficiency.

Background: Multiple Sulfatase Deficiency (MSD) is a rare inherited lysosomal storage disorder characterized by loss of function mutations in the SUMF1 gene that manifests as a severe pediatric neurological disease. There are no available targeted therapies for MSD.

Methods: We engineered a viral vector (AAV9/SUMF1) to deliver working copies of the SUMF1 gene and tested the vector in Sumf1 knock out mice that generally display a median lifespan of 10 days.

Versatile applications of cobalt and copper complexes of biopolymeric Schiff base ligands derived from chitosan.

In the present study, biopolymeric Schiff base (SB) ligands were synthesized from chitosan and isatin. Consequently, their earth abundant transition metal complexes of cobalt and copper were synthesized. All compounds were extensively characterized using FTIR and UV spectroscopy, thermo-gravimetric (TG) analysis, X-ray powder diffraction (XRD) and FESEM (field emission scanning electron microscopy).

Biofouling dynamics and antifouling innovations: Transitioning from traditional biocides to nanotechnological interventions.

Biofouling is a common phenomenon caused by waterborne organisms such as bacteria, diatoms, mussels, barnacles, algae, etc., accumulating on the surfaces of engineering structures submerged under water. This leads to corrosion of such surfaces and decreases their moving efficiency.

Posterior Positivity Distribution Analysis of Subclinical Bluetongue in the Eastern and North-Eastern States of India: A Wakeup Call for Outbreak Preparedness.

Bluetongue (BT) is considered endemic in the southern states of India, with sporadic incidences reported from the northern, western and central parts of India. However, the eastern and north-eastern states of India have not experienced active disease so far. In the recent past, an extensive sero-epidemiological investigation was carried out in the eastern and north-eastern Indian states.