Exploring the structure and nucleic acid interactions of the Leishmania sp. telomerase reverse transcriptase N-terminal region.

Leishmaniasis is a neglected tropical disease caused by protozoans of the Leishmania genus, against which no effective treatment or control is available. Like other eukaryotes, parasite telomeres are maintained by telomerase, a ribonucleoprotein complex vital for genome stability. Its protein component, TERT (telomerase reverse transcriptase), presents four structural and functional domains, with the TEN (Telomerase N-terminal) and TRBD (Telomerase RNA-binding) located at its N-terminal.

Humic Acid Derived from Vermicompost Inhibits Alveolar Bone Degradation and Protects Against Renal Injury in an Experimental Model of Periodontitis.

Periodontal disease (PD) leads to the destruction of supportive tissues through an inflammatory response induced by biofilm accumulation. This low-grade systemic inflammation from PD increases the risk of comorbidities. Among potential therapeutic agents for PD, humic acids (HAs) are notable for their anti-inflammatory and immunomodulatory properties.

Key elements for designing effective second victim support interventions: a focus group study in European clinical settings.

Background: The second victim (SV) experience limits the performance of health and care workers and places patients at risk. Peer support is recognised as the most effective, feasible and acceptable intervention to mitigate its impact.

Objective: To define a set of success factors when designing interventions to support SVs in health and care facilities based on expertise in different European countries.

Assessment of the effects of harvesting period of Clusia fluminensis Planch & Triana fruits on neutralization of the toxic activities of Bothrops jararacussu snake venom.

Snakebite envenomation is a public health issue that can lead to mortality and physical consequences. It is estimated that 5.4 million venomous snake bites occur annually, with 130,000 deaths and 400,000 amputations.

Is there an association between parenting styles, personality traits, and parent-reported sleep bruxism in Brazilian children?

Objective: To explore the relationship between parenting styles and children's personality traits and parental-reported sleep bruxism (SB).

Methods: A total of 301 parents/caregivers of Brazilian children participated in this cross-sectional study and answered an online questionnaire addressing sociodemographic characteristics, sleep-related behaviors and parent-reported SB. The Brazilian versions of the Parenting Styles and Dimensions Questionnaire and the Eysenck Personality Questionnaire-Junior assessed children's parenting styles and personality traits.