Aryl hydrocarbon receptor and IL-13 signaling crosstalk in human keratinocytes and atopic dermatitis.

Introduction: Atopic dermatitis (AD) is an allergic skin disease mediated by skin barrier impairment and IL-13-driven immune response. Activation of the aryl hydrocarbon receptor (AHR) has shown promise in early clinical trials for AD; however, the mechanism by which AHR partially ameliorates AD is not well known.

Methods: Gene expression data from human biopsies were analyzed, and compared to gene expression from RNA-sequencing in our HaCaT cell model system.

Corrosion-Fatigue Performance of 3D-Printed (L-PBF) AlSi10Mg.

Additive manufacturing (AM) allows for optimized part design, reducing weight compared to conventional manufacturing. However, the microstructure, surface state, distribution, and size of internal defects (e.g.

Achieving Precision Medicine in Allergic Disease: Progress and Challenges.

Allergic diseases (atopic dermatitis, food allergy, eosinophilic esophagitis, asthma and allergic rhinitis), perhaps more than many other traditionally grouped disorders, share several overlapping inflammatory pathways and risk factors, though we are still beginning to understand how the relevant patient and environmental factors uniquely shape each disease. Precision medicine is the concept of applying multiple levels of patient-specific data to tailor diagnoses and available treatments to the individual; ideally, a patient receives the right intervention at the right time, in order to maximize effectiveness but minimize morbidity, mortality and cost. While precision medicine in allergy is in its infancy, the recent success of biologics, development of tools focused on large data set integration and improved sampling methods are encouraging and demonstrates the utility of refining our understanding of allergic endotypes to improve therapies.

Tensile Properties of 21-6-9 Austenitic Stainless Steel Built Using Laser Powder-Bed Fusion.

Alloy 21-6-9 is an austenitic stainless steel with high strength, thermal stability at high temperatures, and retained toughness at cryogenic temperatures. This type of steel has been used for aerospace applications for decades, using traditional manufacturing processes. However, limited research has been conducted on this alloy manufactured using laser powder-bed fusion (LPBF) Therefore, in this work, a design of experiment (DOE) was performed to obtain optimized process parameters with regard to low porosity.

Definition and classification of hereditary angioedema.

Hereditary angioedema (HAE) is defined as a rare genetic disease with recurrent episodes of localized bradykinin-mediated swelling of the deep tissues of the skin, respiratory, and gastrointestinal tracts that can be life threatening. Classification of HAE has evolved over time with our further understanding of clinical phenotypes, underlying causes, and available testing. In most cases, HAE is caused by a deficiency of C1-esterase inhibitor (C1-INH) on the Serpin Family G Member 1 (SERPING1) gene, either through decreased amounts of C1-INH protein (C1-INH-HAE, type 1) or decreased function of C1-INH (C1-INH-HAE, type 2).