[Long-COVID, severe course, with congenital bronchiectasis, Williams-Campbell syndrome. Case report].

We present a clinical observation of an 18-year-old female patient with congenital bronchiectasis combined with congenital cystic degeneration of the upper lobes of both lungs, Williams-Campbell syndrome, long-COVID, severe course. The patient was treated in infectious disease department (three times), with subsequent transfer to pulmonology department of Kursk Regional Multi-Purpose Clinical Hospital from 31.01.

[Nonimmunogenic staphylokinase in the treatment of acute ischemic stroke (FRIDA trial results)].

Aim Of The Study: To investigate the efficacy and safety of non-immunogenic staphylokinase (NS) compared with alteplase (A) in patients with acute ischemic stroke (AIS) within 4.5 h after symptom onset.

Material And Methods: 336 patients with IS within 4.

[Endothelial dysfunction mediators in patients with chronic cor pulmonale].

Forty-nine sourses of Russian and foreign literature dedicated to the role of endothelial dysfunction in the development of pulmonary hypertension and chronic cor pulmonale were analyzed. Data on endothelium-dependent vasoactive mediators are presented in the article.

[Pulmonary hypertension, endothelial dysfunction, and their correction with lisinopril in patients with heart failure in combination of ischemic heart disease and chronic obstructive pulmonary disease].

The paper contains review of the role of endothelial dysfunction in heart failure in patients with combination of ischemic heart disease and chronic obstructive pulmonary disease and discussion of results of a study in which it was established that lisinopril (10 mg/day) caused attenuation of pulmonary hypertension, improvement of right ventricular systolic function and diastolic ventricular filling at the background of correction of vascular tone.