[Antiviral activity of 2,3-secotriterpenic hydrazones of lupane and 19beta,28-epoxy-18alpha-oleanane type].

Novel hydrazones of lupane and 19beta,28-epoxy-18alpha-oleanane type have been synthesized via interaction of 2,3-secotriterpenic aldehydonitriles with substituted hydrazines. As a result of investigation of 2,3-secotriterpenic hydrazones antiviral activity to the strain "Indiana" of vesicular stomatitis virus on two models of mammal's line cell infection, acetylhydrazone 1-cyano-2,3-seco-19beta,28-epoxy-18alpha-olean-3-al has been found to have a high prophylactic activity 0.00016 microg/ml to vesicular stomatitis virus and to inhibit a virus reproduction in primarily infected cells in 0.

[Assessment of safety of lyophilized substance of antibacterial peptide complex].

Aim: To assessment acute and chronic toxicity and local irritative effect of antibacterial peptide complex (ABC) substance extracted from interferon preparations.

Materials And Methods: Preclinical assessment of ABC substance was performed according to "Requirements for preclinical study of overall toxicity of new pharmacological substances".

Results: Series of experiments showed that single or prolonged (during 30 days) administration of ABC substance solution to mice intragastrically or rectally in maximal doses did not lead to death of experimental animals or pathological changes in their organs during pathomorphological and histological studies.