The Ivermectin Related Compound Moxidectin Can Target Apicomplexan Importin α and Limit Growth of Malarial Parasites.

Signal-dependent transport into and out of the nucleus mediated by members of the importin (IMP) superfamily is crucial for eukaryotic function, with inhibitors targeting IMPα being of key interest as anti-infectious agents, including against the apicomplexan species and , causative agents of malaria and toxoplasmosis, respectively. We recently showed that the FDA-approved macrocyclic lactone ivermectin, as well as several other different small molecule inhibitors, can specifically bind to and inhibit and IMPα functions, as well as limit parasite growth. Here we focus on the FDA-approved antiparasitic moxidectin, a structural analogue of ivermectin, for its IMPα-targeting and anti-apicomplexan properties for the first time.

Importin α inhibitors act against the differentiated stages of apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii.

Background: Nuclear import, dependent on the transporter importin α (IMPα), is a drug target for apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii. Indeed, a panel of small molecule inhibit interactions between IMPα and nuclear localization signals (NLSs) in vitro and the growth of rapidly dividing stages (P. falciparum blood stages and T.

Retraction: Evaluation of the Efficacy of the HaeNaem Zero Bone Loss Kit in Indirect Sinus Lift Using Osseodensification.

[This retracts the article DOI: 10.7759/cureus.73130.

Correction: Evaluation of the Efficacy of the HaeNaem Zero Bone Loss Kit in Indirect Sinus Lift Using Osseodensification.

[This corrects the article DOI: 10.7759/cureus.73130.

Evaluation of the Efficacy of the HaeNaem Zero Bone Loss Kit in Indirect Sinus Lift Using Osseodensification.

Aim The purpose of this study was to evaluate alveolar height at the antral floor following dental implant placement after an indirect sinus lift using osseodensification (OD) with the HaeNaem bur system. Materials and methods A total of 12 patients seeking implant rehabilitation in the maxillary posterior region were selected for the study. Preoperative cone beam CT (CBCT) was performed to measure the residual crestal bone height (RCBH).