Publications by authors named "S A Palumbo"
Keratinocytes are the most abundant cell type in the human epidermis, the outermost layer of the skin. For years, primary human keratinocytes (HKs) have been used as a crucial tool for studying the pathogenesis of a wide range of skin-related diseases. To mimic the physiological and pathological behavior of human skin, organotypic 3D skin models can be generated by in vitro differentiation of HKs.
View Article and Find Full Text PDFBackground: Several studies reported a reduced rate of accesses to pediatric emergency department (ED) for seizures during COVID-19 pandemic. The aim of our study is to evaluate the attendance to pediatric ED for seizures, as well as the influence of seizure type and personal history of seizures on the rate of admissions during the pandemic period.
Methods: The number and clinical features of patients admitted to the pediatric ED because of seizures were collected at a single hospital in Milan, Italy, between January 2017 and December 2021.
Article Synopsis
- Acute exacerbations of chronic rhinosinusitis (AECRS) are often worsened by rhinovirus (RV) infections, and the study investigates genetic risk factors associated with these infections, focusing on the CDHR3 gene.
- In a year-long study, individuals carrying the minor allele rs6967330 showed significantly higher rates of RV and bacterial infections compared to those with the major allele.
- The study also found that nasal airway cultures from minor allele carriers had higher levels of viral replication and exhibited changes in immune response pathways, suggesting that these genetic factors affect how the body responds to RV infections.
Purpose: The occurrence of genitourinary (GU) toxicity is a common adverse event observed after external beam radiation therapy (EBRT) for prostate cancer (PCa). Recent findings suggest that the dose delivered to specific urinary organs at risk (OARs) such as the ureters, bladder trigone, and urethra is involved in the development of GU toxicity.
Methods And Materials: A multidisciplinary task force including 3 radiation oncologists, a uroradiologist, and a urologist was created in 2022.