Influence of cytokine and intercellular adhesion molecule-1 gene polymorphisms on acute rejection in pediatric renal transplantation.

Immune response regulation by cytokines is a key to understanding AGR. The influence of the functional polymorphisms in genes coding for TNF-alpha (-308G > A), IL-10 (-819C > T, and -1082A > G), IFN-gamma [(CA)n], TGF-beta1 (+869T > C), and iCAM-1 (R241G and E469K), in addition to HLA and gender matching on the presentation of AGR in 51 pediatric renal recipients during a 36-month post-transplantation follow-up were analyzed. Also, donors and a control group were genotyped.

[Renal transplants from anencephalic donors].

Kidney transplants are carried out as any other surgical procedure at specialized third level hospitals. For over 20 years, in Mexico, transplants have been done with kidneys originating from cadavers. Even though this has been of tremendous help, there is still a shortage of donors.