Publications by authors named "S A Mott"
After first-line treatment failure, patients with non-muscle invasive urothelial carcinoma (NMIUC) are recommended to undergo radical cystectomy. However, those unable to pursue radical surgery or desiring bladder preservation require effective salvage therapies. Multi-agent treatment regimens are particularly useful for targeting the complex resistance mechanisms of recurrent UC.
View Article and Find Full Text PDFArticle Synopsis
- National guidelines recommend segmental colectomy for appendiceal neuroendocrine neoplasms larger than 2.0 cm due to risks of lymph node involvement, with conditional overall survival becoming an important prognostic tool.
- A study of 3,541 patients revealed that 16% had positive lymph nodes, and factors like size, depth of invasion, and lymphovascular involvement were correlated with metastasis.
- The findings suggest that more clinicopathologic factors should influence decisions on surgical treatment and surveillance for better survival rates, especially for patients with more aggressive histologies.
Background: Therapeutic strategies to engage anti-tumor innate immunity are still underdeveloped. Imprime PGG (imprime), a pathogen-associated molecular pattern (PAMP), through pattern recognition receptors, successfully illicit a broad-based innate immune response in preclinical models against various cancers. We aimed to study safety and efficacy of imprime in combination with pembrolizumab in advanced stage non-small cell lung cancer (NSCLC).
View Article and Find Full Text PDFArticle Synopsis
- Pelvic exenterations (PEs) are complex surgeries aimed at treating advanced rectal cancer, with the study focusing on national patterns and outcomes instead of single-center data.* -
- From 673 patients, 76% received neoadjuvant chemotherapy and 24% had positive margins after surgery; younger age and post-surgery chemotherapy improved overall survival, while positive margins worsened prognosis.* -
- The study concluded that a significant portion of patients had positive resections, highlighting the importance of achieving negative margins in surgical procedures for better patient outcomes.*