Publications by authors named "S A Modaressi"
Article Synopsis
- A study investigated whether the MenB-4C vaccine, designed for meningococcal serogroup B, could protect against gonorrhea in individuals aged 15-30 years in Northern California from 2016-2021.
- Researchers analyzed health records to compare the prevalence of gonococcal and chlamydial infections among vaccinated and unvaccinated individuals, finding that MenB-4C vaccination reduced the risk of gonococcal mono-infections by 23% in a limited model.
- However, this protective effect disappeared when adjusting for additional confounding factors, and no protection against co-infections of gonorrhea and chlamydia was found.
Purpose: The COVID-19 pandemic impacted testing and incidence of sexually transmitted infections (STIs), with some studies showing uneven effects across sociodemographic groups. We aim to determine whether rates of gonorrhea and chlamydia testing and infections were affected by the pandemic, overall and by subgroups, defined by sociodemographic factors and comorbidities.
Methods: We conducted a retrospective cohort study from January 1, 2016, through December 31, 2022, among adolescents and young adults ages 15-29 years within Kaiser Permanente Northern California (KPNC).
Article Synopsis
- The study aimed to investigate the use of biological response modifiers (BRM) during pregnancy, looking at its prevalence and how it impacts clinical outcomes in infants, vaccination rates, and adverse events post-immunization.
- A total of 2,243 out of over 1.2 million pregnant individuals used BRM, with usage increasing significantly from 2006 to 2017; results indicated no substantial differences in clinical outcomes between infants exposed and not exposed to BRM.
- The findings suggest that in utero exposure to BRM does not raise the risk of serious health issues or vaccine-related adverse events, allowing these infants to receive live-attenuated vaccines as scheduled.
Objectives: To determine whether children aged 4-7 years with a diagnosis of autism spectrum disorders (ASD) were at increased risk of fever, febrile seizures, or emergency department (ED) visits following measles- or pertussis-containing vaccines compared with children without ASD.
Methods: The study included children born between 1995-2012, aged 4-7 years at vaccination, and members of six healthcare delivery systems within Vaccine Safety Datalink. We conducted self-controlled risk interval analyses comparing rates of outcomes in risk and control intervals within each group defined by ASD status, and then compared outcome rates between children with and without ASD, in risk and control intervals, by estimating difference-in-differences using logistic regressions.
Article Synopsis
- Cancer care guidelines emphasize the need for regular distress screening, as about one in three cancer patients experience significant distress, but implementation varies widely.
- A study at Stanford Cancer Center tested a hybrid screening method (electronic and paper) using a modified questionnaire to evaluate health and distress, incorporating workflow changes to integrate with electronic health records.
- Over 53,000 questionnaires were collected, revealing that about 40% of patients screened positively for distress, leading to significant referrals for supportive care, highlighting the method's feasibility for large-scale use.