Metabolism of alcohol by human gastric cells: relation to first-pass metabolism.

Background & Aims: The bioavailability of orally administered alcohol is incomplete, indicating first-pass metabolism. There is debate regarding the site of first-pass metabolism and specifically whether the stomach has the metabolic capacity to account for first-pass metabolism. The aim of this study was to assess ethanol metabolism by human gastric mucosa cells in primary culture.

Metabolism of ethanol in rat gastric cells and its inhibition by cimetidine.

Background/aims: Several studies have shown that the stomach has sufficient alcohol dehydrogenase activity to metabolize a significant amount of alcohol and that cimetidine depresses this alcohol dehydrogenase activity. However, both gastric metabolism of ethanol and its inhibition by cimetidine remain controversial. Given the difficulty in assessing gastric metabolism of ethanol in vivo, this subject was investigated in vitro.

Lymphangiolipoma of the mesentery.

An exceedingly rare tumor was found coincidentally in a young woman who had salpingectomy. The benign tumor was complex in nature and consisted of a lymphangioma and a well-encapsulated lipoma located in the mesentery of the small intestine. This tumor is compared with the similar ones mentioned so far in the literature.