Technetium-99m (99mTc) is a short-lived nanocolloid nuclide widely used by oncologists to diagnose and identify cancer dissemination.
View Article and Find Full Text PDFBiomolecules
August 2024
The enzymatic synthesis of nucleoside derivatives is an important alternative to multi-step chemical methods traditionally used for this purpose. Despite several undeniable advantages of the enzymatic approach, there are a number of factors limiting its application, such as the limited substrate specificity of enzymes, the need to work at fairly low concentrations, and the physicochemical properties of substrates-for example, low solubility. This research conducted by our group is dedicated to the advantages and limitations of using purine nucleoside phosphorylases (PNPs), the main enzymes for the metabolic reutilization of purines, in the synthesis of modified nucleoside analogues.
View Article and Find Full Text PDFThe fractional quantum Hall effect was experimentally discovered in 1982. It was observed that the Hall conductivity σyx of a two-dimensional electron system is quantized, σyx=e2/3h, in the vicinity of the Landau level filling factor ν=1/3. In 1983, Laughlin proposed a trial many-body wave function, which he claimed described a "new state of matter"-a homogeneous incompressible liquid with fractionally charged quasiparticles.
View Article and Find Full Text PDFWith wavelength tunability, free-electron lasers (FELs) are well-suited for generating orbital angular momentum (OAM) beams in a wide photon energy range. We report here the first experimental demonstration of OAM beam generation using an oscillator FEL with the tens of picosecond pulse duration. Lasing around 458 nm, we have produced the four lowest orders of superposed Laguerre-Gaussian beams using a very long FEL resonator of 53.
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