Germline mutations predisposing to melanoma and associated malignancies and syndromes: a narrative review.

The pathogenesis of melanoma is influenced by a complex combination of environmental factors and individual genetic susceptibility. Familial melanoma refers to cases where there are two first-degree relatives with a melanoma diagnosis. Less strict definitions include second-degree relatives or even three or more of any degree from the same family, although this is not clearly defined in the literature.

A multi-center study on the use of lidocaine thermogel for pain control in outpatient operative hysteroscopy.

Objectives: This study aimed to explore the use of an anesthetic lidocaine thermogel in outpatient operative hysteroscopies. Specifically, it assessed the safety, tolerability, and ease of use of the gel, as well as its potential for pain reduction during the procedure.

Study Design: This was a multicenter observational study conducted in 9 gynecological units between March 2023 and January 2024.

Unveiling interactions mediated by B vitamins between diatoms and their associated bacteria from cocultures.

Unveiling the interactions among phytoplankton and bacteria at the level of species requires axenic isolates to experimentally demonstrate their mutual effects. In this study, we describe the interactions among the diatoms Pseudo-nitzschia granii and Chaetoceros tenuissimus and their associated bacterial species, isolated from surface water of a coastal upwelling system using coculture experiments. Microalgae growth was assessed in axenic monocultures or in coculture with each of their co-isolated bacteria in the presence or absence of B vitamins.

Analysis of Shannon's entropy to contrast between the Embodied and Neurocentrist hypothesis of conscious experience.

We usually accept that consciousness is in the brain. This statement corresponds to a Neurocentrist view. However, with all the physical and physiological data currently available, a convincing explanation of how consciousness emerges has not been given this topic is aborded by Anil Seth (2021).

In situ metagenomics: A platform for rapid sequencing and analysis of metagenomes in less than one day.

We present here a complete system for metagenomic analysis that allows performing the sequencing and analysis of a medium-size metagenome in less than one day. This unprecedented development was possible due to the conjunction of state-of-the-art experimental and computational advances: a portable laboratory suitable for DNA extraction and sequencing with nanopore technology; the powerful metagenomic analysis pipeline SqueezeMeta, capable to provide a complete analysis in a few hours and using scarce computational resources; and tools for the automatic inspection of the results via a graphical user interface, that can be coupled to a web server to allow remote visualization of data (SQMtools and SQMxplore). We have tested the feasibility of our approach in the sequencing of the microbiota associated to volcanic rocks in La Palma, Canary Islands.