Publications by authors named "S A L Montalvao"
This guidance document has been prepared on behalf of the International Council for Standardization in Haematology (ICSH). The aim of the document is to provide guidance and recommendations for the performance and interpretation of activated partial thromboplastin time (APTT) and prothrombin time (PT) plasma mixing tests in clinical laboratories in all regions of the world. The following areas are included in this document: preanalytical, analytical, postanalytical, and quality assurance considerations as they relate to the proper performance and interpretation of plasma mixing tests.
View Article and Find Full Text PDFContext.—: The prothrombin time (PT) and activated partial thromboplastin time (APTT) are screening tests used to detect congenital or acquired bleeding disorders. An unexpected PT and/or APTT prolongation is often evaluated using a mixing test with normal plasma.
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- - The study investigates the fibrinolytic system in cancer patients, focusing on its role in tumor growth and mortality, using a fluorometric method to measure thrombin and plasmin generation in 323 cancer patients and 148 healthy controls.
- - Results indicated that cancer patients showed a hypercoagulable profile, with alterations in thrombin production and increased plasmin generation, as 68 patients died during a 12-month follow-up.
- - Two specific thrombin parameters, maximum amplitude and area under the curve, were linked to higher mortality risk in cancer patients, while no significant associations were found regarding plasmin generation.