Publications by authors named "S A Kusmartsev"
Article Synopsis
- Hyaluronan (HA) is a key component of the extracellular matrix in tumors, where its synthesis and breakdown are crucial for tumor growth and progression.
- In cancer, excessive HA production leads to its degradation, resulting in small molecular weight HA fragments that can promote various biological processes, including blood vessel formation and immune suppression.
- Recent studies focus on the disrupted HA metabolism in urologic cancers like prostate and bladder cancer, suggesting potential new treatment strategies based on these findings.
Article Synopsis
- * In cancer, there tends to be increased production and breakdown of hyaluronan, leading to the buildup of small fragments that promote issues like inflammation, tumor growth, and immune suppression.
- * The text outlines a method for studying hyaluronan metabolism using precision-cut tissue slice cultures from freshly removed cancer tissue, specifically focusing on human urothelial carcinoma.
Hyaluronan (HA) is known to be a prominent component of the extracellular matrix in tumors, and many solid cancers are characterized by aberrant HA metabolism resulting in increased production in tumor tissue. HA has been implicated in regulating a variety of cellular functions in tumor cells and tumor-associated stromal cells, suggesting that altered HA metabolism can influence tumor growth and malignancy at multiple levels. Importantly, increased HA production in cancer is associated with enhanced HA degradation due to high levels of expression and activity of hyaluronidases (Hyal).
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